As heard on the show:

Desmond had a barrow in the market place
Molly is the singer in a band
Desmond says to Molly, "Girl I like your face."
And Molly says this as she takes him by the hand

Ob-la-di, ob-la-da life goes on - bra
La, La how the life goes on. (2X)

In a couple of years they have built a home sweet home
With a couple of kids running in the yard
Of Desmond & Molly Jones

Happy ever-after in the market place
Desmond lets the children lend a hand
Molly stays at home and does her pretty face
And in the evening still sings it with the band

Ob-la-di, ob-la-da life goes on - bra
La, La how the life goes on. (3X)
Well if you want some fun - say "Ob-la-di-bla-da"

Life Goes On was the first TV series to feature a person with Downs Syndrome as a co-star.

Kellie Martin, who co-starred on Life Goes On and E.R. (she was killed off in 1999). She was also the star of a Appalachian melodrama Christy.